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Georgette N. Jones

Georgette N. Jones

Assistant Professor of Biology

Tel: 301-696-3657
Email: jonesg@hood.edu
Office: Hodson Science & Technology Center, Room 158

Education

  • Ph.D., Ohio State University (Molecular, Cellular, and Developmental Biology)
  • B.S., University of Wisconsin – La Crosse (Biology – cellular and molecular biology)

Courses taught

  • BIOL 112 Biology of Food and Nutrition
  • BIOL 314 Developmental Biology
  • BIOL 470 Developmental Biology (Senior Seminar)
  • BMS 590 Advanced Topics: Techniques in Model Organisms of Development and Disease

Biography

Dr. Jones, assistant professor of biology, teaches introductory biology, upper level developmental biology, and graduate level lab courses. Her background is interdisciplinary and includes molecular, cellular, and developmental biology; mouse and human genetics; cancer biology; and histology. She has published several review articles, primary research articles, and a book chapter relating to her work on both a rare endocrine-related tumor syndrome called the Carney Complex (CNC) and a more commonly inherited tumor syndrome called Neurofibromatosis Type I (NF1).

Research and teaching interests

My research focus is on the molecular signaling involved in Schwann cell tumor initiation. During graduate school and in my post-doc I cultured and studied primary mouse Schwann cells, whose normal function is to wrap around and insulate peripheral nerve axons, and tumor-derived Schwann cells from mouse models of both CNC and NF1. Some of the molecular signaling events that cause Schwann cell tumors in these syndromes are well known, however there are still many mysteries to be revealed about tumor initiation in the Schwann cells. I aim to understand the molecular signaling interactions between newly identified “modifier” genes that can impact tumor initiation in Schwann cells – making them either resistant or susceptible to developing into tumors. Additionally, I intend to study the interaction between a major protein involved in CNC and the protein product of the NF1 gene with the goal of understanding the function of their interaction during tumor initiation.

Selected publications

  • Manchanda PK, Jones GN, Lee AA, Pringle DR, Zhang M, Yu L, La Perle KMD, and Kirschner LS. Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors. Oncogene. 2013 Jul 25;32(30):3491-9. View here.
  • Jones GN and Reilly KM. “Dissection of Complex Genetic and Epigenetic Interactions Underlying NF1 Cancer Susceptibility Using Mouse Models.” (Book Chapter) 2012 Neurofibromatosis Type I: Molecular and Cellular Biology. Springer Eds: Upadhyaya M, and Cooper D. ISBN: 978-3-642-32864-03. View here.
  • Yin Z, Pringle DR, Jones GN, Kelly KM, and Kirschner LS. Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a. Mol Endocrinol. 2011 Oct;25(10):1786-93. View here.
  • Jones GN, Manchanda PK, Pringle DR, Zhang M, and Kirschner LS. Mouse models of endocrine tumors. (Review) Best Pract Res Clin Endocrinol Metab. 2010 Jun;24(3):451-60. View here.
  • Jones GN, Pringle DR, Yin Z, Carlton MM, Powell KA, Weinstein MB, Toribio RE, La Perle KMD, and Kirschner LS. Neural crest specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification. Mol Endocinol. 2010 Aug;24(8):1559-68. View here.
  • Kirschner LS, Yin Z, Jones GN, and Mahoney, E. Mouse models of altered protein kinase A signaling. (Review) Endocrine-Related Cancer. 2009 Sept 16(3):773-93. View here.
  • Jones GN, Tep C, Towns WH II, Mihai G, Tonks ID, Kay GF, Schmalbrock PM, Stemmer-Rachamimov AO, Yoon SO, and Kirschner LS. Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production. Neoplasia. 2008 Nov;10(11):1213-21. View here.
  • Nadella KS, Jones GN, Trimboli A, Stratakis CA, Leone G, and Kirschner LS. Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition. Cancer Res. 2008 Apr 15;68(8):2671-7. View here.
  • Yin Z, Jones GN, Towns WH II, Zhang X, Abel ED, Binkley PF, Jarjoura D, and Kirschner LS. Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation. 2008 Mar 18;117(11):1414-22. View here.